For research designed to include individuals in Correctional settings, which regulation must be adhered to?

In research that involves individuals in correctional settings, it is critical to adhere to Subpart C: Additional Protections for Prisoners. This set of regulations is specifically designed to protect the rights and welfare of prisoners participating in research studies. The unique circumstances and vulnerabilities of incarcerated individuals necessitate these additional protections to ensure ethical treatment and safeguard against coercion and undue influence.

Subpart C establishes safeguards that include ensuring that participation in research is voluntary and that prisoners are fully informed about the research, including any potential risks. It also addresses issues related to informed consent, requiring that consent be obtained in a manner that respects the rights of prisoners. These regulations are essential because prisoners may feel pressured to participate due to their circumstances, and their ability to decline participation without negative consequences is crucial.

The other options pertain to different vulnerable populations and ethical concerns. Subpart A covers the basic HHS regulations applicable to all human subjects research, while Subpart B focuses on additional protections for pregnant women and Subpart D addresses additional protections for children. Each of these subsystems is vital, but when it comes specifically to individuals in correctional settings, Subpart C is the appropriate and necessary regulation to follow.